Dataset Information

Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.

ABSTRACT:

Objective

Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC).

Methods

Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing.

Results

83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31.3%. During a median follow-up of 45.5?months, patients with LUSI developed more local and distant recurrences (local: 19.2% vs. 3.5%, P?=?.03; distant: 50% vs. 17.5%, P?=?.004) and progression events (73.1% vs. 26.3%, P?P?P?=?.007), and a 2.6-fold increase in the risk of death (P?=?.02). In the subgroup of patients with UPSC, mutations were identified in 54 genes, including TP53 (80%), PPP2R1A (40%), and PTEN (22.5%). Frequent mutations in the PTEN-PI3K-AKT signaling pathway were found in patients with tumor in the upper uterine segment only (P?=?.04), with PTEN being mutated in 29% of the samples (P?=?.07).

Conclusion

Type II endometrial cancers presenting in the LUS have a significantly worse prognosis and this might be associated with a unique mutational profile.

SUBMITTER: Kogan L

PROVIDER: S-EPMC6003406 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Publications

Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.

Kogan Liron L Octeau David D Amajoud Zainab Z Abitbol Jeremie J Laskov Ido I Ferenczy Alex A Pelmus Manuela M Eisenberg Neta N Kessous Roy R Lau Susie S Yasmeen Amber A Gotlieb Walter H WH Salvador Shannon S

Gynecologic oncology reports 20180319

<h4>Objective</h4>Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC).<h4>Methods</h4>Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing.<h4>Results</h4>83 patients with type II endometrial ...[more]

PMID: 29915797

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Dataset Information

Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.

Objective

Methods

Results

Conclusion

Publications

Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors.

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