Ontology highlight
ABSTRACT:
SUBMITTER: Herman-Bausier P
PROVIDER: S-EPMC6003445 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Herman-Bausier Philippe P Labate Cristina C Towell Aisling M AM Derclaye Sylvie S Geoghegan Joan A JA Dufrêne Yves F YF
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
Clumping factor A (ClfA), a cell-wall-anchored protein from <i>Staphylococcus aureus</i>, is a virulence factor in various infections and facilitates the colonization of protein-coated biomaterials. ClfA promotes bacterial adhesion to the blood plasma protein fibrinogen (Fg) via molecular forces that have not been studied so far. A unique, yet poorly understood, feature of ClfA is its ability to favor adhesion to Fg at high shear stress. Unraveling the strength and dynamics of the ClfA-Fg intera ...[more]