Physics of lumen growth.
Ontology highlight
ABSTRACT:
SUBMITTER: Dasgupta S
PROVIDER: S-EPMC6003502 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Physics of lumen growth.
Dasgupta Sabyasachi S Gupta Kapish K Zhang Yue Y Viasnoff Virgile V Prost Jacques J
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters ...[more]
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