Osmotic stabilization prevents cochlear synaptopathy after blast trauma.
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ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC6003510 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Osmotic stabilization prevents cochlear synaptopathy after blast trauma.
Kim Jinkyung J Xia Anping A Grillet Nicolas N Applegate Brian E BE Oghalai John S JS
Proceedings of the National Academy of Sciences of the United States of America 20180507 21
Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and were K<sup>+</sup>-depe ...[more]
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