Ontology highlight
ABSTRACT:
SUBMITTER: Monteiro I
PROVIDER: S-EPMC6003551 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Monteiro Inês I Vigano Selena S Faouzi Mohamed M Treilleux Isabelle I Michielin Olivier O Ménétrier-Caux Christine C Caux Christophe C Romero Pedro P de Leval Laurence L
Oncotarget 20180601 42
<h4>Background</h4>CD73 is an ectoenzyme involved in the production of adenosine. It exerts immunosuppressive and protumoral roles and has emerged as a potential immuno-oncology target.<h4>Results</h4>CD73 expression was detected in TC in 54% of melanoma metastases, involving < 50% TC in the majority of the cases, with variable intensity. CD73 expression was significantly associated with a lower Breslow's depth of the primary lesion and was more frequent in patients having received prior non-sur ...[more]