Ontology highlight
ABSTRACT:
SUBMITTER: Van Dis E
PROVIDER: S-EPMC6003617 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cell reports 20180501 5
There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein subunit vaccine elicit long-lasting protective immunity to Mycobacterium tuberculosis in the mouse model. Subcutaneous administration of this vaccine provides equivalent protection to that of the live attenuated vaccine strain Bacille Calmette-Guérin (BCG). Pro ...[more]