7SL RNA in vertebrate red blood cells.
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ABSTRACT:
SUBMITTER: Talhouarne GJS
PROVIDER: S-EPMC6004055 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
7SL RNA in vertebrate red blood cells.
Talhouarne Gaëlle J S GJS Gall Joseph G JG
RNA (New York, N.Y.) 20180423 7
We report that 7SL, the RNA component of the signal recognition particle (SRP), is an abundant noncoding RNA (ncRNA) in mature red blood cells (RBCs) of human, mouse, and the frog <i>Xenopus.</i> 7SL RNA in RBCs is not associated with the canonical proteins of the SRP. Instead, it coimmunoprecipitates from a lysate of RBCs with a number of membrane-binding proteins. Human and mouse RBCs also contain a previously undescribed 68 nt RNA, sRN7SL, derived from the "S domain" of 7SL RNA. We discuss th ...[more]
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