Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC6004244 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Wu Jiandong J Wei Juan J Hogan John D JD Chopra Pradeep P Joshi Apoorva A Lu Weigang W Klein Joshua J Boons Geert-Jan GJ Lin Cheng C Zaia Joseph J
Journal of the American Society for Mass Spectrometry 20180321 6
Among dissociation methods, negative electron transfer dissociation (NETD) has been proven the most useful for glycosaminoglycan (GAG) sequencing because it produces informative fragmentation, a low degree of sulfate losses, high sensitivity, and translatability to multiple instrument types. The challenge, however, is to distinguish positional sulfation. In particular, NETD has been reported to fail to differentiate 4-O- versus 6-O-sulfation in chondroitin sulfate decasaccharide. This raised the ...[more]