Ontology highlight
ABSTRACT:
SUBMITTER: Luo D
PROVIDER: S-EPMC6004286 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Luo Dandan D Goel Shreya S Liu Hai-Jun HJ Carter Kevin A KA Jiang Dawei D Geng Jumin J Kutyreff Christopher J CJ Engle Jonathan W JW Huang Wei-Chiao WC Shao Shuai S Fang Chao C Cai Weibo W Lovell Jonathan F JF
ACS nano 20171205 12
Doxorubicin (Dox)-loaded stealth liposomes (similar to those in clinical use) can incorporate small amounts of porphyrin-phospholipid (PoP) to enable chemophototherapy (CPT). PoP is also an intrinsic and intrabilayer <sup>64</sup>Cu chelator, although how radiolabeling impacts drug delivery has not yet been assessed. Here, we show that <sup>64</sup>Cu can radiolabel the stable bilayer of preformed Dox-loaded PoP liposomes with inclusion of 1% ethanol without inducing drug leakage. Dox-PoP liposo ...[more]