Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective.
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ABSTRACT:
SUBMITTER: Meli M
PROVIDER: S-EPMC6004406 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective.
Meli Massimiliano M Gasset Maria M Colombo Giorgio G
Frontiers in molecular biosciences 20180611
The self-assembly of proteins and peptides into amyloids is a key feature of an increasing number of diseases. Amyloid fibrils display a unique surface reactivity endowing the sequestration of molecules such as MicroRNAs, which can be the active moiety of the toxic action. To test this hypothesis we studied the recognition between a model RNA and two different steric zipper spines using molecular dynamics simulations. We found that the interaction occurs and displays peptide-sequence dependence. ...[more]
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