Ontology highlight
ABSTRACT:
SUBMITTER: DeLoughery A
PROVIDER: S-EPMC6004469 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
DeLoughery Aaron A Lalanne Jean-Benoît JB Losick Richard R Li Gene-Wei GW
Proceedings of the National Academy of Sciences of the United States of America 20180524 24
Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in <i>Bacillus subtilis</i>, was originally identified for its cleavage activity toward the <i>cggR-gapA</i> operon, an event that differentiates the synthesis of a glycolytic enzyme from its transcriptional regulator. A three-protein Y-complex (YlbF, YmcA, and YaaT) was recently identified as also being r ...[more]