How electrostatic networks modulate specificity and stability of collagen.
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ABSTRACT:
SUBMITTER: Zheng H
PROVIDER: S-EPMC6004475 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
How electrostatic networks modulate specificity and stability of collagen.
Zheng Hongning H Lu Cheng C Lan Jun J Fan Shilong S Nanda Vikas V Xu Fei F
Proceedings of the National Academy of Sciences of the United States of America 20180529 24
One-quarter of the 28 types of natural collagen exist as heterotrimers. The oligomerization state of collagen affects the structure and mechanics of the extracellular matrix, providing essential cues to modulate biological and pathological processes. A lack of high-resolution structural information limits our mechanistic understanding of collagen heterospecific self-assembly. Here, the 1.77-Å resolution structure of a synthetic heterotrimer demonstrates the balance of intermolecular electrostati ...[more]
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