Ontology highlight
ABSTRACT:
SUBMITTER: Capeding MR
PROVIDER: S-EPMC6005168 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Capeding Maria Rosario MR Teshome Samuel S Saluja Tarun T Syed Khalid Ali KA Kim Deok Ryun DR Park Ju Yeon JY Yang Jae Seung JS Kim Yang Hee YH Park Jiwook J Jo Sue-Kyoung SK Chon Yun Y Kothari Sudeep S Yang Seon-Young SY Ham Dong Soo DS Ryu Ji Hwa JH Hwang Hee-Seong HS Mun Ju-Hwan JH Lynch Julia A JA Kim Jerome H JH Kim Hun H Excler Jean-Louis JL Sahastrabuddhe Sushant S
Vaccine 20180601 26
<h4>Background</h4>Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2-14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overcome by conjugation of the Vi to a carrier protein. A typhoid conjugate vaccine composed of Vi polysaccharide conjugated to diphtheria toxoid (Vi-DT) has been developed. The ...[more]