Ontology highlight
ABSTRACT:
SUBMITTER: Savva CG
PROVIDER: S-EPMC6005192 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Savva Christos G CG Dewey Jill S JS Deaton John J White Rebecca L RL Struck Douglas K DK Holzenburg Andreas A Young Rye R
Molecular microbiology 20080801 4
Holins control the length of the infection cycle of tailed phages (the Caudovirales) by oligomerizing to form lethal holes in the cytoplasmic membrane at a time dictated by their primary structure. Nothing is currently known about the physical basis of their oligomerization or the structure of the oligomers formed by any known holin. Here we use electron microscopy and single-particle analysis to characterize structures formed by the bacteriophage lambda holin (S105) in vitro. In non-ionic or mi ...[more]