Ontology highlight
ABSTRACT:
SUBMITTER: Sy LK
PROVIDER: S-EPMC6005341 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Sy Lai-King LK Lok Chun-Nam CN Wang Juan-Yu JY Liu Yungen Y Cheng Lu L Wan Pui-Ki PK Leung Chi-Ting CT Cao Bei B Kwong Wai-Lun WL Chang Raymond Chuen-Chung RC Che Chi-Ming CM
Chemical science 20160122 5
The inhibition of amyloid β (Aβ) peptide production is a key approach in the development of therapeutics for the treatment of Alzheimer's disease (AD). We have identified that timosaponins consisting of sarsasapogenin (SSG) as the aglycone can effectively lower the production of Aβ peptides and stimulate neurite outgrowth in neuronal cell cultures. Structure-activity relationship studies revealed that the <i>cis</i>-fused AB ring, 3β-configuration, spiroketal F-ring and 25<i>S</i>-configuration ...[more]