Ontology highlight
ABSTRACT:
SUBMITTER: Hultman R
PROVIDER: S-EPMC6005365 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hultman Rainbo R Ulrich Kyle K Sachs Benjamin D BD Blount Cameron C Carlson David E DE Ndubuizu Nkemdilim N Bagot Rosemary C RC Parise Eric M EM Vu Mai-Anh T MT Gallagher Neil M NM Wang Joyce J Silva Alcino J AJ Deisseroth Karl K Mague Stephen D SD Caron Marc G MG Nestler Eric J EJ Carin Lawrence L Dzirasa Kafui K
Cell 20180301 1
Brain-wide fluctuations in local field potential oscillations reflect emergent network-level signals that mediate behavior. Cracking the code whereby these oscillations coordinate in time and space (spatiotemporal dynamics) to represent complex behaviors would provide fundamental insights into how the brain signals emotional pathology. Using machine learning, we discover a spatiotemporal dynamic network that predicts the emergence of major depressive disorder (MDD)-related behavioral dysfunction ...[more]