Ontology highlight
ABSTRACT:
SUBMITTER: Igarashi A
PROVIDER: S-EPMC6005449 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20180507 24
Defects in phosphatase and tensin homolog (PTEN) are associated with neurological disorders and tumors. PTEN functions at two primary intracellular locations: the plasma membrane and the nucleus. At the membrane, PTEN functions as a phosphatidylinositol (3,4,5)-trisphosphate phosphatase and suppresses PI 3-kinase signaling that drives cell growth and tumorigenesis. However, the <i>in vivo</i> function of nuclear PTEN is unclear. Here, using CRISPR/Cas9, we generated a mouse model in which PTEN l ...[more]