Ontology highlight
ABSTRACT:
SUBMITTER: Jacobs HN
PROVIDER: S-EPMC6005649 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jacobs Heather N HN Rathod Sona S Wolf Matthew T MT Elisseeff Jennifer H JH
The AAPS journal 20161024 1
Micronized porcine urinary bladder matrix (UBM) is an extracellular matrix biomaterial that has immunomodulatory and pro-regenerative properties. The objective of this study was to assess the ability of UBM to alter disease progression in a mouse model of post-traumatic osteoarthritis (OA). Ten-week-old wild-type C57BL/6 male mice underwent anterior cruciate ligament transection (ACLT) to induce OA. Two weeks after ACLT, UBM (50 mg/mL) or saline was injected into the mouse joint. At 4 and 8 week ...[more]