Ontology highlight
ABSTRACT:
SUBMITTER: James MA
PROVIDER: S-EPMC6005686 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
James Michael A MA Vikis Haris G HG Tate Everett E Rymaszewski Amy L AL You Ming M
Cancer research 20131223 4
The transmembrane protein CLPTM1L is overexpressed in non-small cell lung cancer, where it protects tumor cells from genotoxic apoptosis. Here, we show that RNA interference-mediated blockade of CLPTM1L inhibits K-Ras-induced lung tumorigenesis. CLPTM1L expression was required in vitro for morphologic transformation by H-RasV12 or K-RasV12, anchorage-independent growth, and survival of anoikis of lung tumor cells. Mechanistic investigations indicated that CLPTM1L interacts with phosphoinositide ...[more]