Ontology highlight
ABSTRACT:
SUBMITTER: von Ardenne B
PROVIDER: S-EPMC6006178 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
von Ardenne Benjamin B Mechelke Martin M Grubmüller Helmut H
Nature communications 20180618 1
Scattering experiments with femtosecond high-intensity free-electron laser pulses provide a new route to macromolecular structure determination. While currently limited to nano-crystals or virus particles, the ultimate goal is scattering on single biomolecules. The main challenges in these experiments are the extremely low signal-to-noise ratio due to the very low expected photon count per scattering image, often well below 100, as well as the random orientation of the molecule in each shot. Her ...[more]