Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.
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ABSTRACT:
SUBMITTER: Wegert J
PROVIDER: S-EPMC6006309 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.
Wegert Jenny J Vokuhl Christian C Collord Grace G Del Castillo Velasco-Herrera Martin M Farndon Sarah J SJ Guzzo Charlotte C Jorgensen Mette M Anderson John J Slater Olga O Duncan Catriona C Bausenwein Sabrina S Streitenberger Heike H Ziegler Barbara B Furtwängler Rhoikos R Graf Norbert N Stratton Michael R MR Campbell Peter J PJ Jones David Tw DT Koelsche Christian C Pfister Stefan M SM Mifsud William W Sebire Neil N Sparber-Sauer Monika M Koscielniak Ewa E Rosenwald Andreas A Gessler Manfred M Behjati Sam S
Nature communications 20180618 1
Soft tissue tumors of infancy encompass an overlapping spectrum of diseases that pose unique diagnostic and clinical challenges. We studied genomes and transcriptomes of cryptogenic congenital mesoblastic nephroma (CMN), and extended our findings to five anatomically or histologically related soft tissue tumors: infantile fibrosarcoma (IFS), nephroblastomatosis, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma of the kidney. A key finding is recurrent mutation of EGFR in CMN by inte ...[more]
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