Deamidation of human proteins.
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ABSTRACT:
SUBMITTER: Robinson NE
PROVIDER: S-EPMC60067 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Publications
Deamidation of human proteins.
Robinson N E NE Robinson A B AB
Proceedings of the National Academy of Sciences of the United States of America 20011016 22
Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been performed. These rates suggest that deamidation is a biologically relevant phenomenon in a remarkably large percentage of human proteins. ...[more]
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