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Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

ABSTRACT: Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.

SUBMITTER: Sneddon JB

PROVIDER: S-EPMC6007036 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Sneddon Julie B JB Tang Qizhi Q Stock Peter P Bluestone Jeffrey A JA Roy Shuvo S Desai Tejal T Hebrok Matthias M

Cell stem cell 20180601 6

Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for ...[more]

PMID: 29859172

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