Ontology highlight
ABSTRACT:
SUBMITTER: Sneddon JB
PROVIDER: S-EPMC6007036 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Sneddon Julie B JB Tang Qizhi Q Stock Peter P Bluestone Jeffrey A JA Roy Shuvo S Desai Tejal T Hebrok Matthias M
Cell stem cell 20180601 6
Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for ...[more]