Ontology highlight
ABSTRACT:
SUBMITTER: Spasic A
PROVIDER: S-EPMC6007268 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Spasic Aleksandar A Berger Kyle D KD Chen Jonathan L JL Seetin Matthew G MG Turner Douglas H DH Mathews David H DH
Nucleic acids research 20180601 10
RNA folding free energy change nearest neighbor parameters are widely used to predict folding stabilities of secondary structures. They were determined by linear regression to datasets of optical melting experiments on small model systems. Traditionally, the optical melting experiments are analyzed assuming a two-state model, i.e. a structure is either complete or denatured. Experimental evidence, however, shows that structures exist in an ensemble of conformations. Partition functions calculate ...[more]