Ontology highlight
ABSTRACT:
SUBMITTER: Evans JP
PROVIDER: S-EPMC6007465 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Evans Jonathan P JP Winiarski Boleslaw K BK Sutton Paul A PA Jones Robert P RP Ressel Lorenzo L Duckworth Carrie A CA Pritchard D Mark DM Lin Zhi-Xiu ZX Fretwell Vicky L VL Tweedle Elizabeth M EM Costello Eithne E Goldring Christopher E CE Copple Ian M IM Park B Kevin BK Palmer Daniel H DH Kitteringham Neil R NR
Oncotarget 20180605 43
Nrf2 is a transcription factor that regulates cellular stress response and irinotecan-metabolising pathways. Its aberrant activity has been reported in a number of cancers, although relatively few studies have explored a role for Nrf2 in colorectal cancer (CRC). This study assessed the expression of Nrf2 in patient CRC tissues and explored the effect of Nrf2 modulation alone, or in combination with irinotecan, in human (HCT116) and murine (CT26) cell lines <i>in vitro</i> and in an orthotopic sy ...[more]