Ontology highlight
ABSTRACT:
SUBMITTER: Swinburne IA
PROVIDER: S-EPMC6008045 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Swinburne Ian A IA Mosaliganti Kishore R KR Upadhyayula Srigokul S Upadhyayula Srigokul S Liu Tsung-Li TL Hildebrand David G C DGC Tsai Tony Y-C TY Chen Anzhi A Al-Obeidi Ebaa E Fass Anna K AK Malhotra Samir S Engert Florian F Lichtman Jeff W JW Kirchhausen Tomas T Betzig Eric E Megason Sean G SG
eLife 20180619
The inner ear is a fluid-filled closed-epithelial structure whose function requires maintenance of an internal hydrostatic pressure and fluid composition. The endolymphatic sac (ES) is a dead-end epithelial tube connected to the inner ear whose function is unclear. ES defects can cause distended ear tissue, a pathology often seen in hearing and balance disorders. Using live imaging of zebrafish larvae, we reveal that the ES undergoes cycles of slow pressure-driven inflation followed by rapid def ...[more]