Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila.
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ABSTRACT:
SUBMITTER: Cornelissen T
PROVIDER: S-EPMC6008047 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Deficiency of parkin and PINK1 impairs age-dependent mitophagy in <i>Drosophila</i>.
Cornelissen Tom T Vilain Sven S Vints Katlijn K Gounko Natalia N Verstreken Patrik P Vandenberghe Wim W
eLife 20180529
Mutations in the genes for PINK1 and parkin cause Parkinson's disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo is still scarce. Here, we generated a <i>Drosophila</i> model expressing the mitophagy probe mt-Keima. Using live mt-Keima imaging and correlative light and electron microscopy (CLEM), we show that mitophagy occurs in muscle cells and dopaminergic neuro ...[more]
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