Modulation of specific intestinal epithelial progenitors by enteric neurons.
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ABSTRACT:
SUBMITTER: Bjerknes M
PROVIDER: S-EPMC60082 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Publications
Modulation of specific intestinal epithelial progenitors by enteric neurons.
Proceedings of the National Academy of Sciences of the United States of America 20010925 22
The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetro ...[more]
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