Distinct Circuits for Recovery of Eye Dominance and Acuity in Murine Amblyopia.
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ABSTRACT:
SUBMITTER: Stephany CE
PROVIDER: S-EPMC6008222 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Distinct Circuits for Recovery of Eye Dominance and Acuity in Murine Amblyopia.
Stephany Céleste-Élise CÉ Ma Xiaokuang X Dorton Hilary M HM Wu Jie J Solomon Alexander M AM Frantz Michael G MG Qiu Shenfeng S McGee Aaron W AW
Current biology : CB 20180607 12
Degrading vision by one eye during a developmental critical period yields enduring deficits in both eye dominance and visual acuity. A predominant model is that "reactivating" ocular dominance (OD) plasticity after the critical period is required to improve acuity in amblyopic adults. However, here we demonstrate that plasticity of eye dominance and acuity are independent and restricted by the nogo-66 receptor (ngr1) in distinct neuronal populations. Ngr1 mutant mice display greater excitatory s ...[more]
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