Ontology highlight
ABSTRACT:
SUBMITTER: Kular L
PROVIDER: S-EPMC6008330 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kular Lara L Liu Yun Y Ruhrmann Sabrina S Zheleznyakova Galina G Marabita Francesco F Gomez-Cabrero David D James Tojo T Ewing Ewoud E Lindén Magdalena M Górnikiewicz Bartosz B Aeinehband Shahin S Stridh Pernilla P Link Jenny J Andlauer Till F M TFM Gasperi Christiane C Wiendl Heinz H Zipp Frauke F Gold Ralf R Tackenberg Björn B Weber Frank F Hemmer Bernhard B Strauch Konstantin K Heilmann-Heimbach Stefanie S Rawal Rajesh R Schminke Ulf U Schmidt Carsten O CO Kacprowski Tim T Franke Andre A Laudes Matthias M Dilthey Alexander T AT Celius Elisabeth G EG Søndergaard Helle B HB Tegnér Jesper J Harbo Hanne F HF Oturai Annette B AB Olafsson Sigurgeir S Eggertsson Hannes P HP Halldorsson Bjarni V BV Hjaltason Haukur H Olafsson Elias E Jonsdottir Ingileif I Stefansson Kari K Olsson Tomas T Piehl Fredrik F Ekström Tomas J TJ Kockum Ingrid I Feinberg Andrew P AP Jagodic Maja M
Nature communications 20180619 1
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is particularly affected and displays methylation-sensitive regulatory properties in vitro. Causal inference and Mendelian randomization provide evidence that HLA variants mediate risk for MS via change ...[more]