Unknown

Dataset Information

0

CD4+ T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity.


ABSTRACT: Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T lymphocytes have an important role in hippocampal plasticity, learning, and memory, although the precise mechanisms by which they act on the brain remain elusive. Using a mouse model of EE, we show here that CD4+ T cells are essential for spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. However, CD4+ lymphocytes do not influence EE-induced neurogenesis in the DG of the hippocampus, by contrast to what we previously demonstrated for CD8+ T cells. Importantly, CD4+ T cells located in the choroid plexus have a specific transcriptomic signature as a function of the living environment. Our study highlights the contribution of CD4+ T cells in the brain plasticity and function.

SUBMITTER: Zarif H 

PROVIDER: S-EPMC6008389 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

altmetric image

Publications

CD4<sup>+</sup> T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity.

Zarif Hadi H   Hosseiny Salma S   Paquet Agnès A   Lebrigand Kevin K   Arguel Marie-Jeanne MJ   Cazareth Julie J   Lazzari Anne A   Heurteaux Catherine C   Glaichenhaus Nicolas N   Chabry Joëlle J   Guyon Alice A   Petit-Paitel Agnès A  

Frontiers in synaptic neuroscience 20180613


Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T lymphocytes have an important role in hippocampal plasticity, learning, and memory, although the precise mechanisms by which they act on the brain remain elusive.  ...[more]

Similar Datasets

| S-EPMC5841814 | biostudies-literature
| S-EPMC5048127 | biostudies-literature
| S-EPMC6334594 | biostudies-literature
2019-06-04 | GSE115507 | GEO
| S-EPMC4118923 | biostudies-literature
| S-EPMC4396478 | biostudies-literature
| S-EPMC6621222 | biostudies-literature
| S-EPMC8152950 | biostudies-literature
| S-EPMC9901197 | biostudies-literature
| S-EPMC7034265 | biostudies-literature