Dataset Information

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.

ABSTRACT:

Objectives

To evaluate the association between blood pressure (BP) measurements and adverse outcomes in women with pre-eclampsia.

Study design

A prospective cohort study of women with pre-eclampsia admitted to three South African tertiary facilities. BP was measured using the CRADLE Vital Signs Alert (VSA), incorporated with a traffic light early warning system; green: systolic BP <140 mmHg and diastolic BP <90 mmHg, yellow: systolic BP 140-159 and/or diastolic BP 90-109 mmHg (but neither is above the upper threshold), red: systolic BP ≥160 mmHg and/or diastolic BP ≥110 mmHg.

Main outcome measures

Maternal: death, eclampsia, stroke, kidney injury; process measures: magnesium sulfate use, Critical Care Unit (CCU) admission; perinatal: stillbirth, neonatal death, preterm delivery.

Results

Of 1547 women with pre-eclampsia (including 42 twin pregnancies), 33.0% of women triggered a red light on admission and 78.6% at their highest BP. Severe hypertension and adverse outcomes were common across yellow and red categories. Comparing admission red to yellow lights, there was a significant increase in kidney injury (OR 1.74, CI 1.31-2.33, trend test p = .003), magnesium sulfate use (OR 3.40, CI 2.24-5.18, p < .001) and CCU admission (OR 1.50, CI 1.18-1.91, p < .001), but not for maternal death, eclampsia, extended perinatal death or preterm delivery.

Conclusion

The CRADLE VSA, with integrated traffic light early warning system, can identify women who are hypertensive, at increased risk of severe pre-eclampsia complications and in need of escalation of care. Women who triggered a red light were at increased risk of kidney injury, magnesium sulfate use and CCU admission.

SUBMITTER: Nathan HL

PROVIDER: S-EPMC6008490 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Publications

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.

Nathan Hannah L HL Seed Paul T PT Hezelgrave Natasha L NL De Greeff Annemarie A Lawley Elodie E Anthony John J Hall David R DR Steyn Wilhelm W Chappell Lucy C LC Shennan Andrew H AH

Pregnancy hypertension 20171121

<h4>Objectives</h4>To evaluate the association between blood pressure (BP) measurements and adverse outcomes in women with pre-eclampsia.<h4>Study design</h4>A prospective cohort study of women with pre-eclampsia admitted to three South African tertiary facilities. BP was measured using the CRADLE Vital Signs Alert (VSA), incorporated with a traffic light early warning system; green: systolic BP <140 mmHg and diastolic BP <90 mmHg, yellow: systolic BP 140-159 and/or diastolic BP 90-109 mmHg (but ...[more]

PMID: 29175171

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Dataset Information

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.

Objectives

Study design

Main outcome measures

Results

Conclusion

Publications

Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study.

Similar Datasets

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