Ontology highlight
ABSTRACT:
SUBMITTER: Duell AK
PROVIDER: S-EPMC6008736 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Duell Anna K AK Pankow James F JF Peyton David H DH
Chemical research in toxicology 20180523 6
E-liquids usually contain significant nicotine, which will exist primarily in two forms, monoprotonated and free-base, the proportions of which are alterable through the effective pH of the medium. The fraction of nicotine in the free-base form is α<sub>fb</sub>, with 0 ≤ α<sub>fb</sub> ≤ 1. When dosed via aerosol, the two nicotine forms have different mechanisms and kinetics of delivery, as well as differing implications for harshness of the inhaled aerosol, so α<sub>fb</sub> is relevant regard ...[more]