Ontology highlight
ABSTRACT:
SUBMITTER: Mohanan V
PROVIDER: S-EPMC6008784 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Mohanan Vishnu V Nakata Toru T Desch A Nicole AN Lévesque Chloé C Boroughs Angela A Guzman Gaelen G Cao Zhifang Z Creasey Elizabeth E Yao Junmei J Boucher Gabrielle G Charron Guy G Bhan Atul K AK Schenone Monica M Carr Steven A SA Reinecker Hans-Christian HC Daly Mark J MJ Rioux John D JD Lassen Kara G KG Xavier Ramnik J RJ
Science (New York, N.Y.) 20180201 6380
Polymorphisms in <i>C1orf106</i> are associated with increased risk of inflammatory bowel disease (IBD). However, the function of C1orf106 and the consequences of disease-associated polymorphisms are unknown. Here we demonstrate that C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6. By limiting cytohesin-1-dependent ARF6 activation, C1orf106 stabilizes adherens junctions. Consistent ...[more]