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Evaluation of defense strategy against Influenza A in cell line models.


ABSTRACT: : Our results demonstrated that sialidases with different specificity and activity can be selected as genes providing antiviral defence. Combining chosen sialidases with different activity together with tissue-specific promoters would provide an optimal level of desialilation to prevent infection. Tissue specific expression of the sialidases could protect domestic birds from infection.

SUBMITTER: Antonova E 

PROVIDER: S-EPMC6008855 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Evaluation of the potential defensive strategy against Influenza A in cell line models.

Antonova Ekaterina E   Glazova Olga O   Gaponova Anna A   Eremyan Aykaz A   Grebenkina Natalya N   Zvereva Svetlana S   Volkova Natalya N   Volchkov Pavel P  

F1000Research 20180219


<b>Background:</b> Influenza virus can cause both seasonal infections and unpredictable pandemics. Rapidly evolving avian H5N1 and  H7N9 viruses have a potential pandemic threat for humans. Since avian Influenza can be transmitted by domestic birds, serving as a key link between wild birds and humans, an effective measure to control the influenza transmission would be eradication of the infection in poultry. It is known that the virus penetrates into the cell through binding with the terminal ol  ...[more]

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