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NICD-mediated notch transduction regulates the different fate of chicken primordial germ cells and spermatogonial stem cells.

ABSTRACT: Background:Notch signaling is mainly regulated by Notch1 during development of chicken germ stem cells; however, the molecular mechanisms that contribute to generation of these germ stem cells have not been thoroughly investigated. Results:In our studies, Overexpression of the Notch1 NICD promoted development of the reproductive ridge, but inhibited the formation of seminiferous tubules. The formation efficiency of PGCs in the reproductive ridge following overexpression of NICD (7.5%?±?0.11) was significantly higher than that (4.9%?±?0.17, p?

SUBMITTER: Zuo Q 

PROVIDER: S-EPMC6009047 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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NICD-mediated notch transduction regulates the different fate of chicken primordial germ cells and spermatogonial stem cells.

Zuo Qisheng Q   Zhang Chen C   Jin Kai K   Jing Jin J   Sun Changhua C   Ahmed Mahmoud F MF   Song Jiuzhou J   Zhang Yani Y   Chen Guohong G   Li Bichun B  

Cell & bioscience 20180619

<h4>Background</h4>Notch signaling is mainly regulated by Notch1 during development of chicken germ stem cells; however, the molecular mechanisms that contribute to generation of these germ stem cells have not been thoroughly investigated.<h4>Results</h4>In our studies, Overexpression of the Notch1 NICD promoted development of the reproductive ridge, but inhibited the formation of seminiferous tubules. The formation efficiency of PGCs in the reproductive ridge following overexpression of NICD (7  ...[more]

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