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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis.

ABSTRACT: The system of the hypervalent iodine(III) reagent FPID and (4-MeOC₆H₄)₃P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction.

SUBMITTER: Liu D

PROVIDER: S-EPMC6009197 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis.

Liu Dan D Guo Ya-Li YL Qu Jin J Zhang Chi C

Beilstein journal of organic chemistry 20180522

The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis. Four peptides with biological activities were synthesized through SPPS and the bioactive cyclic heptapeptide pseudostellarin D was obtained via solution-phase peptide synthesis. It is worth noting that FPID can be readily regenerated after the peptide coupling reaction. ...[more]

PMID: 29977383

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