Dataset Information

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China.

ABSTRACT:

Objectives

We aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, and examine the possible modifiers in the association among a general population of Chinese adults.

Design

A cross-sectional study.

Setting

The study was conducted within 21 communities in Lianyungang of Jiangsu province, China.

Participants

A total of 26?648 participants aged ?35 years and with no antihypertensive drug use were included in the final analysis.

Results

Overall, there was a positive association between tHcy concentrations and SBP (per 5 ?mol/L tHcy increase: adjusted ?=0.45?mm Hg; 95%?CI 0.29 to 0.61) or DBP levels (per 5 ?mol/L tHcy increase: adjusted ?=0.47?mm Hg; 95%?CI 0.35 to 0.59). Compared with participants with tHcy <10 ?mol/L, significantly higher SBP levels were found in those with tHcy concentrations of 10 to <15 (adjusted ?=0.80?mm Hg; 95%?CI 0.32 to 1.28) and ?15 µmol/L (adjusted ?=1.79?mm Hg; 95%?CI 1.20 to 2.37; p for trend <0.001). Consistently, significantly higher DBP levels were found in participants with tHcy concentrations of 10 to <15 (adjusted ?=0.86?mm Hg; 95%?CI 0.49 to 1.22) and ?15 µmol/L (adjusted ?=2.01?mm Hg; 95%?CI 1.57 to 2.46; p for trend <0.001), respectively as compared with those with <10 ?mol/L. Furthermore, a stronger association between tHcy and SBP (p for interaction=0.009) or DBP (p for interaction=0.067) was found in current alcohol drinkers.

Conclusion

Serum tHcy concentrations were positively associated with both SBP and DBP levels in a general Chinese adult population. The association was stronger in current alcohol drinkers.

SUBMITTER: Wu H

PROVIDER: S-EPMC6009617 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China.

Wu Hongxu H Wang Binyan B Ban Qianyun Q Chen Lulu L Yan Dong D Yu Yaren Y Song Yun Y Liu Chengzhang C Cao Jingjing J Zhang Jingping J Zhang Yuanyuan Y Zhang Tao T Zhang Hao H Guo Huiyuan H Tang Genfu G Zhang Yan Y Li Jianping J Huo Yong Y Zang Tonghua T Qin Xianhui X Xu Xiping X

BMJ open 20180619 6

<h4>Objectives</h4>We aimed to evaluate the relation of total homocysteine (tHcy) concentrations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, and examine the possible modifiers in the association among a general population of Chinese adults.<h4>Design</h4>A cross-sectional study.<h4>Setting</h4>The study was conducted within 21 communities in Lianyungang of Jiangsu province, China.<h4>Participants</h4>A total of 26 648 participants aged ≥35 years and with no anti ...[more]

PMID: 29921686

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Dataset Information

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China.

Objectives

Design

Setting

Participants

Results

Conclusion

Publications

Association of total homocysteine with blood pressure in a general population of Chinese adults: a cross-sectional study in Jiangsu province, China.

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