Ontology highlight
ABSTRACT:
SUBMITTER: Xie Q
PROVIDER: S-EPMC6009976 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Xie Qiong Q Zheng Zhaoxi Z Shao Biyun B Fu Wei W Xia Zheng Z Li Wei W Sun Jian J Zheng Wei W Zhang Weiwei W Sheng Wei W Zhang Qihong Q Chen Hongzhuan H Wang Hao H Qiu Zhuibai Z
Journal of enzyme inhibition and medicinal chemistry 20171201 1
Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer's disease (AD). We reported here the design of new carbamates using pharmacophore model strategy to modulate both cholinesterase and amyloidogenesis. A five-feature pharmacophore model was generated based on 25 carbamate-type training set compounds. (-)-Meptazinol carbamates that superimposed well upon the model were designed and ...[more]