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Tyrosinase inhibitory components from Aloe vera and their antiviral activity.

ABSTRACT: A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8?±?0.9?µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

SUBMITTER: Kim JH

PROVIDER: S-EPMC6010052 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Tyrosinase inhibitory components from Aloe vera and their antiviral activity.

Kim Jang Hoon JH Yoon Ju-Yeon JY Yang Seo Young SY Choi Seung-Kook SK Kwon Sun Jung SJ Cho In Sook IS Jeong Min Hee MH Ho Kim Young Y Choi Gug Seoun GS

Journal of enzyme inhibition and medicinal chemistry 20161025 1

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC<sub>50</sub> value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. ...[more]

PMID: 27778516

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