Ontology highlight
ABSTRACT:
SUBMITTER: Evain-Bana E
PROVIDER: S-EPMC6010111 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Evain-Bana Emilie E Schiavo Lucie L Bour Christophe C Lanfranchi Don Antoine DA Berardozzi Simone S Ghirga Francesca F Bagrel Denyse D Botta Bruno B Hanquet Gilles G Mori Mattia M
Journal of enzyme inhibition and medicinal chemistry 20161023 1
The cell division cycle 25 phosphatases (CDC25A, B, and C; E.C. 3.1.3.48) are key regulator of the cell cycle in human cells. Their aberrant expression has been associated with the insurgence and development of various types of cancer, and with a poor clinical prognosis. Therefore, CDC25 phosphatases are a valuable target for the development of small molecule inhibitors of therapeutic relevance. Here, we used an integrated strategy mixing organic chemistry with biological investigation and molec ...[more]