Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC6010231 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Zhou Weiyin W Goldin Lynn L Wang Mingyi M McMaster Mary L ML Jones Kristine K Burdett Laurie L Chanock Stephen J SJ Yeager Meredith M Dean Michael M Caporaso Neil E NE
British journal of haematology 20180424 5
Recurrent large-scale somatic copy number alterations (SCNAs), and somatic point mutations can be analysed to stratify patients with chronic lymphocytic leukaemia (CLL) into distinct prognostic groups. To investigate the relationship between SCNAs and somatic mutations, we performed whole-exome sequencing and single nucleotide polymorphism microarray analyses on 98 CLL patients from 40 families with a high burden of CLL. Overall, 69 somatic mutations in 29 CLL driver genes were detected among 45 ...[more]