Immunity drives TET1 regulation in cancer through NF-?B.
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ABSTRACT:
SUBMITTER: Collignon E
PROVIDER: S-EPMC6010319 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Immunity drives <i>TET1</i> regulation in cancer through NF-κB.
Collignon Evelyne E Canale Annalisa A Al Wardi Clémence C Bizet Martin M Calonne Emilie E Dedeurwaerder Sarah S Garaud Soizic S Naveaux Céline C Barham Whitney W Wilson Andrew A Bouchat Sophie S Hubert Pascale P Van Lint Carine C Yull Fiona F Sotiriou Christos C Willard-Gallo Karen K Noel Agnès A Fuks François F
Science advances 20180620 6
Ten-eleven translocation enzymes (TET1, TET2, and TET3), which induce DNA demethylation and gene regulation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are often down-regulated in cancer. We uncover, in basal-like breast cancer (BLBC), genome-wide 5hmC changes related to <i>TET1</i> regulation. We further demonstrate that <i>TET1</i> repression is associated with high expression of immune markers and high infiltration by immune cells. We identify in BLBC tissues an an ...[more]
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