Ontology highlight
ABSTRACT:
SUBMITTER: Biesemann N
PROVIDER: S-EPMC6010423 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Biesemann Nadine N Ried Janina S JS Ding-Pfennigdorff Danping D Dietrich Axel A Rudolph Christine C Hahn Steffen S Hennerici Wolfgang W Asbrand Christian C Leeuw Thomas T Strübing Carsten C
Scientific reports 20180620 1
Mitochondrial dysfunction is increasingly recognized as a contributor to age-related muscle loss and functional impairment. Therefore, we developed a high throughput screening strategy that enabled the identification of compounds boosting mitochondrial energy production in a human skeletal muscle cell model. Screening of 7949 pure natural products revealed 22 molecules that significantly increased oxygen consumption and ATP levels in myotubes. One of the most potent compounds was the flavanone h ...[more]