Ontology highlight
ABSTRACT:
SUBMITTER: Julander JG
PROVIDER: S-EPMC6010449 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Julander Justin G JG Siddharthan Venkatraman V Park Albert H AH Preston Elizabeth E Mathur Pranav P Bertolio Michael M Wang Hong H Zukor Katherine K Van Wettere Arnaud J AJ Sinex Donal G DG Morrey John D JD
Scientific reports 20180620 1
Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days' post coitus (dpc). Viral RNA, antigen and infectious virus were detected in some, but not all, maternal and fetal tissues at various times during gestation. Fetuses of infected dams had significant intrauterine ...[more]