Ontology highlight
ABSTRACT:
SUBMITTER: Singh M
PROVIDER: S-EPMC6010463 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Singh Manjulata M Warita Katsuhiko K Warita Tomoko T Faeder James R JR Lee Robin E C REC Sant Shilpa S Oltvai Zoltán N ZN
Scientific reports 20180620 1
Cell-to-cell differences in protein expression in normal tissues and tumors are a common phenomenon, but the underlying principles that govern this heterogeneity are largely unknown. Here, we show that in monolayer cancer cell-line cultures, the expression of the five metabolic enzymes of serine-glycine synthesis (SGS), including its rate-limiting enzyme, phosphoglycerate dehydrogenase (PHGDH), displays stochastic cell-to-cell variation. By contrast, in cancer cell line-derived three-dimensional ...[more]