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The developing premature infant gut microbiome is a major factor shaping the microbiome of neonatal intensive care unit rooms.


ABSTRACT: BACKGROUND:The neonatal intensive care unit (NICU) contains a unique cohort of patients with underdeveloped immune systems and nascent microbiome communities. Patients often spend several months in the same room, and it has been previously shown that the gut microbiomes of these infants often resemble the microbes found in the NICU. Little is known, however, about the identity, persistence, and absolute abundance of NICU room-associated bacteria over long stretches of time. Here, we couple droplet digital PCR (ddPCR), 16S rRNA gene surveys, and recently published metagenomics data from infant gut samples to infer the extent to which the NICU microbiome is shaped by its room occupants. RESULTS:Over 2832 swabs, wipes, and air samples were collected from 16 private-style NICU rooms housing very low birth weight (

SUBMITTER: Brooks B 

PROVIDER: S-EPMC6011520 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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The developing premature infant gut microbiome is a major factor shaping the microbiome of neonatal intensive care unit rooms.

Brooks Brandon B   Olm Matthew R MR   Firek Brian A BA   Baker Robyn R   Geller-McGrath David D   Reimer Sophia R SR   Soenjoyo Karina R KR   Yip Jennifer S JS   Dahan Dylan D   Thomas Brian C BC   Morowitz Michael J MJ   Banfield Jillian F JF  

Microbiome 20180620 1


<h4>Background</h4>The neonatal intensive care unit (NICU) contains a unique cohort of patients with underdeveloped immune systems and nascent microbiome communities. Patients often spend several months in the same room, and it has been previously shown that the gut microbiomes of these infants often resemble the microbes found in the NICU. Little is known, however, about the identity, persistence, and absolute abundance of NICU room-associated bacteria over long stretches of time. Here, we coup  ...[more]

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