Ontology highlight
ABSTRACT:
SUBMITTER: Inman CF
PROVIDER: S-EPMC6012511 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Inman Charlotte F CF Eldershaw Suzy A SA Croudace Joanne E JE Davies Nathaniel J NJ Sharma-Oates Archana A Rai Tanuja T Pearce Hayden H Sirovica Mirjana M Chan Y L Tracey YLT Chan Y L Tracey YLT Verma Kriti K Zuo Jianmin J Nagra Sandeep S Kinsella Francesca F Nunnick Jane J Amel-Kashipaz Rasoul R Craddock Charles C Malladi Ram R Moss Paul P
JCI insight 20180517 10
Allogeneic stem cell transplantation (allo-SCT) can cure some patients with hematopoietic malignancy, but this relies on the development of a donor T cell alloreactive immune response. T cell activity in the first 2 weeks after allo-SCT is crucial in determining outcome, despite the clinical effects of the early alloreactive immune response often not appearing until later. However, the effect of the allogeneic environment on T cells is difficult to study at this time point due to the effects of ...[more]