Ontology highlight
ABSTRACT:
SUBMITTER: Lancel S
PROVIDER: S-EPMC6012521 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lancel Steve S Hesselink Matthijs Kc MK Woldt Estelle E Rouillé Yves Y Dorchies Emilie E Delhaye Stephane S Duhem Christian C Thorel Quentin Q Mayeuf-Louchart Alicia A Pourcet Benoit B Montel Valérie V Schaart Gert G Beton Nicolas N Picquet Florence F Briand Olivier O Salles Jean Pierre JP Duez Hélène H Schrauwen Patrick P Bastide Bruno B Bailleul Bernard B Staels Bart B Sebti Yasmine Y
JCI insight 20180503 9
Metabolic stresses such as dietary energy restriction or physical activity exert beneficial metabolic effects. In the liver, endospanin-1 and endospanin-2 cooperatively modulate calorie restriction-mediated (CR-mediated) liver adaptations by controlling growth hormone sensitivity. Since we found CR to induce endospanin protein expression in skeletal muscle, we investigated their role in this tissue. In vivo and in vitro endospanin-2 triggers ERK phosphorylation in skeletal muscle through an auto ...[more]