Ontology highlight
ABSTRACT:
SUBMITTER: Fukushima A
PROVIDER: S-EPMC6012574 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Fukushima Arata A Zhang Liyan L Huqi Alda A Lam Victoria H VH Rawat Sonia S Altamimi Tariq T Wagg Cory S CS Dhaliwal Khushmol K KK Hornberger Lisa K LK Kantor Paul F PF Rebeyka Ivan M IM Lopaschuk Gary D GD
JCI insight 20180517 10
A dramatic increase in cardiac fatty acid oxidation occurs following birth. However, cardiac hypertrophy secondary to congenital heart diseases (CHDs) delays this process, thereby decreasing cardiac energetic capacity and function. Cardiac lysine acetylation is involved in modulating fatty acid oxidation. We thus investigated what effect cardiac hypertrophy has on protein acetylation during maturation. Eighty-four right ventricular biopsies were collected from CHD patients and stratified accordi ...[more]